Progesterone and the Uterus

Note: To find all references on this subject, search for the categories “progesterone” AND “uterus” using our Research Search Tool.

Research Summary

Progesterone or progestins are a necessary adjunct to estrogen therapy in women who have a uterus (i.e., who have not had a hysterectomy) because of the risk of endometrial (uterine) cancer when estrogen is given alone. Progesterone has an antiproliferative effect and therefore protects the uterus.

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